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The expanding field of poly(ADP‐ribosyl)ation reactions

Identifieur interne : 001D58 ( Main/Exploration ); précédent : 001D57; suivant : 001D59

The expanding field of poly(ADP‐ribosyl)ation reactions

Auteurs : Antoinette Hakmé [France] ; Heng-Kuan Wong [France] ; Françoise Dantzer [France] ; Valérie Schreiber [France]

Source :

EMBO reports [ 1469-221X ] ; 2008-10.

RBID : ISTEX:0F92AFF275757F003CF8A32B025E99C88C0BB0B1

Abstract

Poly(ADP‐ribosyl)ation is a post‐translational modification of proteins that is mediated by poly(ADP‐ribose) polymerases (PARPs). Although the existence and nature of the nucleic acid‐like molecule poly(ADP‐ribose) (PAR) has been known for 40 years, understanding its biological functions—originally thought to be only the regulation of chromatin superstructure when DNA is broken—is still the subject of intense research. Here, we review the mechanisms controlling the biosynthesis of this complex macromolecule and some of its main biological functions, with an emphasis on the most recent advances and hypotheses that have developed in this rapidly growing field.

Url:

https://api.istex.fr/ark:/67375/WNG-CN7062G0-L/fulltext.pdf

DOI: 10.1038/embor.2008.191

Affiliations:

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Le document en format XML

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The expanding field of poly(ADP‐ribosyl)ation reactions

The expanding field of poly(ADP‐ribosyl)ation reactions

Source :

Abstract

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Le document en format XML

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